Working at the cellular level to promote joint health

Cosamin® works at the cellular level inside the joint to help protect the cartilage.
Cartilage in the joint is produced and maintained by its own specialized cells, called chondrocytes.

In a healthy joint, there is a natural, ongoing process in which old cartilage components are broken down and replaced by new components. As part of this process, chondrocytes, release chemicals that trigger certain enzymes that degrade cartilage.

Normally, the breakdown and production of cartilage are in balance, so that your cartilage is maintained. But there are many factors that can disrupt this balance by causing cartilage to break down:

  • Age
  • Being overweight
  • Too much activity—or too little
  • Injury
  • Your genes

In addition, cartilage lacks a direct blood supply and has to get nutrients from the joint fluid. If this process is interrupted by any of the factors listed above, it can disrupt the balance. This leads to the continual loss of the protective cartilage. And that, in turn, can eventually result in damage to the bone—and joint discomfort and deterioration.

Cosamin® helps by inhibiting biomarkers associated with cartilage breakdown as you age:


Biomarker
How it can affect joint health

High-sensitivity C-reactive protein (hsCRP)
An indicator of processes that can negatively impact joint health

Interleukin-6 (IL-6)
Interferes with the production of key structural proteins in cartilage extracellular matrix (Type II Collagen and Aggrecan) and induces the expression of matrix metalloproteinases (MMPs).

Matrix metalloproteinases (MMPs)
Play a role in breaking down cartilage

Interleukin 8 (IL-8)
Plays a role in processes that can negatively impact joint health

Prostaglandin E2 (PGE2)
A lipid signaling molecule (substance) associated with joint discomfort and cartilage breakdown

Cyclooxygenase-2 (COX-2)
Involved in the production of PGE2 which is associated with joint discomfort and cartilage breakdown


Biomarker
How it can affect joint health

High-sensitivity C-reactive protein (hsCRP)
An indicator of processes that can negatively impact joint health

Interleukin-6 (IL-6)
Interferes with the production of key structural proteins in cartilage extracellular matrix (Type II Collagen and Aggrecan) and induces the expression of matrix metalloproteinases (MMPs).

Matrix metalloproteinases (MMPs)
Play a role in breaking down cartilage

Interleukin 8 (IL-8)
Plays a role in processes that can negatively impact joint health

Prostaglandin E2 (PGE2)
A lipid signaling molecule (substance) associated with joint discomfort and cartilage breakdown

Cyclooxygenase-2 (COX-2)
Involved in the production of PGE2 which is associated with joint discomfort and cartilage breakdown

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