Working at the Cellular Level
to Promote Joint Health

Cosamin® DS and Cosamin® ASU work at the cellular level inside the joint to help support cartilage. Cartilage in the joint is produced and maintained by its own specialized cells, called chondrocytes. In a healthy joint, there is a natural, on-going process in which chondrocytes release chemicals that trigger enzymes that break down cartilage. Cosamin® DS and Cosamin® ASU help inhibit certain enzymes that break down cartilage.

#1 Researched Glucosamine / Chondroitin Brand
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Why Joint Cartilage Breaks Down

Normally, the breakdown and production of cartilage are in balance, so that your cartilage is maintained. But there are many factors that can disrupt this balance by causing cartilage to break down:

  • Age
  • Being overweight
  • Too much activity - or too little
  • Injury
  • Your genes

In addition, cartilage lacks a direct blood supply and has to get nutrients from the joint fluid. If this process is interrupted by any of the factors listed above, it can disrupt the balance. This leads to the continual loss of the protective cartilage. And that, in turn, can eventually result in damage to the bone—and joint discomfort and deterioration.

Cosamin® DS and Cosamin® ASU Help by Inhibiting Biomarkers Associated with Cartilage Breakdown

Biomarker How it can affect your health
High-sensitivity C-reactive protein (hsCRP) An indicator of processes that can negatively impact joint health
Interleukin-6 (IL-6) Interferes with the production of key structural proteins in cartilage extracellular matrix (Type II Collagen and Aggrecan) and induces the expression of matrix metalloproteinases (MMPs)
Matrix metalloproteinases (MMPs) Play a role in breaking down cartilage
Interleukin 8 (IL-8) Plays a role in processes that can negatively impact joint health
Prostaglandin E2 (PGE2) A lipid signaling molecule (substance) associated with joint discomfort and cartilage breakdown
Cyclooxygenase-2 (COX-2) Involved in the production of PGE2 which is associated with joint discomfort and cartilage breakdown

Quality You Can Trust

Cosamin products are backed by over 80 quality checks, to meet our high standards and yours.

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Cosamin Success Stories

"I have used other products, but I keep coming back to Cosamin! It is the best product I have ever tried, and it really works."

Lynda, FL

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Lynda's testimonial for Cosamin